DEMEROL Injection is indicated for preoperative medication, help of anesthesia, for obstetrical analgesia, and with the management of pain extreme enough to have to have an opioid analgesic and for which alternate therapies are inadequate. (one)
Animal Data official reproductive and developmental toxicology experiments for meperidine have not been done.
recurring slow intravenous Injections of fractional doses (e.g., ten mg/mL) or continuous intravenous infusion of a far more dilute Option (e.g., one mg/mL) really should be applied. The dose should be titrated on the requirements with the affected individual and may depend upon the premedication and sort of anesthesia remaining used, the features of The actual affected individual, and the nature and duration of the operative method.
DEMEROL Injection is indicated with the management of ache critical enough to need an opioid analgesic and for which different solutions are inadequate.
The concomitant use of cimetidine may perhaps decrease the clearance and volume of distribution of meperidine also the development on the metabolite, normeperidine, in nutritious subjects
If concomitant usage of acyclovir and DEMEROL Injection is necessary, watch sufferers for respiratory melancholy and sedation at Regular intervals.
“health care provider browsing” (browsing several prescribers to get additional prescriptions) is popular among the folks who abuse medicines and individuals with substance use disorder. Preoccupation with obtaining sufficient discomfort reduction might be acceptable behavior in a individual with insufficient pain control.
g., phenothiazines or basic anesthetics) [see Drug Interactions (7)]. keep track of these patients for indications of hypotension soon after initiating or titrating the dosage of DEMEROL Injection. In individuals with circulatory shock, DEMEROL Injection could cause vasodilation that can even more lessen cardiac output and blood pressure. stay away from the usage of DEMEROL Injection in clients with circulatory shock.
DEMEROL Injection shouldn't be utilized for an prolonged time period unless the soreness continues to be serious adequate to require an opioid analgesic and for which alternative treatment method selections go on to be inadequate.
When a narcotic medication is applied for a long time, it may turn out to be practice-forming, leading to mental or Actual physical dependence. having said that, people who have continuing ache should not Enable the fear of dependence maintain them from using narcotics To alleviate their ache. psychological dependence (dependancy) is unlikely to arise when narcotics are utilized for this purpose.
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In a person physically depending on opioids, administration from the suggested usual dosage of the antagonist will precipitate an acute withdrawal syndrome. The severity on the withdrawal indicators expert will rely upon the degree of Bodily dependence and also the dose of the antagonist administered.
alter the dosage to acquire an suitable stability concerning management of discomfort and opioid-associated adverse reactions.
g., nausea, vomiting, diarrhea) and may be fatal. The onset of indicators commonly takes place within a number of hrs to a couple of days of concomitant use but may possibly occur later than that. Discontinue DEMEROL Injection if serotonin syndrome is suspected.